Reconstituted human breast milk PCBs as potent inducers of aryl hydrocarbon hydroxylase
Identifieur interne : 005219 ( Main/Exploration ); précédent : 005218; suivant : 005220Reconstituted human breast milk PCBs as potent inducers of aryl hydrocarbon hydroxylase
Auteurs : Andrew Parkinson [Canada] ; Larry W. Robertson [Canada] ; Stephen Safe [Canada]Source :
- Biochemical and Biophysical Research Communications [ 0006-291X ] ; 1980.
English descriptors
Abstract
The major polychlorinated biphenyl (PCB) components identified in human breast milk have been synthesized and a reconstituted breast milk PCB mixture representing the average levels determined in the Osaka Prefecture in Japan has been prepared. The dose effecting the half-maximal (ED50) induction of rat hepatic microsomal aryl hydrocarbon hydroxylase (AHH) for the reconstituted breast milk PCBs (ED50 ∼12 μmol·kg−1) was approximately seven times less than the ED50 for the commercial PCB mixture, Kanechlor 500. The increased biological potency of the former mixture reflects the preferential bioconcentration of the toxic PCB congeners, 2,3,3′,4,4′-penta-, 2,3′,4,4′,5-penta- and 2,3,3′,4,4′,5-hexachlorobiphenyl.
Url:
DOI: 10.1016/0006-291X(80)91438-2
Affiliations:
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Robertson</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>The Guelph-Waterloo Centre for Graduate Work in Chemistry Department of Chemistry, Environmental Biochemistry Unit University of Guelph Guelph</wicri:regionArea><wicri:noRegion>Environmental Biochemistry Unit University of Guelph Guelph</wicri:noRegion></affiliation></author><author><name sortKey="Safe, Stephen" sort="Safe, Stephen" uniqKey="Safe S" first="Stephen" last="Safe">Stephen Safe</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>The Guelph-Waterloo Centre for Graduate Work in Chemistry Department of Chemistry, Environmental Biochemistry Unit University of Guelph Guelph</wicri:regionArea><wicri:noRegion>Environmental Biochemistry Unit University of Guelph Guelph</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Biochemical and Biophysical Research Communications</title><title level="j" type="abbrev">YBBRC</title><idno type="ISSN">0006-291X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1980">1980</date><biblScope unit="volume">96</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="882">882</biblScope><biblScope unit="page" to="889">889</biblScope></imprint><idno type="ISSN">0006-291X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-291X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AHH</term><term>B[a]P</term><term>CO</term><term>DMAP</term><term>EIC</term><term>MC</term><term>PB</term><term>PCBs</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The major polychlorinated biphenyl (PCB) components identified in human breast milk have been synthesized and a reconstituted breast milk PCB mixture representing the average levels determined in the Osaka Prefecture in Japan has been prepared. The dose effecting the half-maximal (ED50) induction of rat hepatic microsomal aryl hydrocarbon hydroxylase (AHH) for the reconstituted breast milk PCBs (ED50 ∼12 μmol·kg−1) was approximately seven times less than the ED50 for the commercial PCB mixture, Kanechlor 500. The increased biological potency of the former mixture reflects the preferential bioconcentration of the toxic PCB congeners, 2,3,3′,4,4′-penta-, 2,3′,4,4′,5-penta- and 2,3,3′,4,4′,5-hexachlorobiphenyl.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Parkinson, Andrew" sort="Parkinson, Andrew" uniqKey="Parkinson A" first="Andrew" last="Parkinson">Andrew Parkinson</name></noRegion><name sortKey="Robertson, Larry W" sort="Robertson, Larry W" uniqKey="Robertson L" first="Larry W." last="Robertson">Larry W. Robertson</name><name sortKey="Safe, Stephen" sort="Safe, Stephen" uniqKey="Safe S" first="Stephen" last="Safe">Stephen Safe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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